Status : Verified
| Personal Name | Gonzales, Ryan August C. |
|---|---|
| Resource Title | Drug Release Kinetics of Bio-based Synthesized Silver Nanoparticles using Rice (Oryza sativa) Straw and its Epirubicin Conjugation for Potential Cancer Applications |
| Date Issued | 14 February 2025 |
| Abstract | Silver nanoparticles (AgNPs) have been extensively studied in the biomedical field for cancer therapy and drug delivery applications due to their unique physicochemical properties. However, most studies in drug delivery applications report AgNPs synthesized using the chemical route, which involves toxic and costly reagents. To provide a safer and more cost-effective alternative, several studies have utilized biological resources and by-products to synthesize AgNPs mainly for antimicrobial and anticancer activities, but most of them lack insights on drug delivery capabilities. This study explored the sustainable synthesis of silver nanoparticles (AgNPs) using rice straw, an abundant agricultural waste product in the Philippines, and evaluated its potential drug delivery applications in liver cancer treatment by conjugating it with a chemotherapy drug, Epirubicin (EPI). AgNPs were synthesized using rice straw extracts acting as both the reducing and stabilizing agents, and results were confirmed through UV-Vis spectroscopy showing a spectral peak at 392 nm under specific conditions: 140 minutes reaction time, 14 mg/mL rice straw extract, and 6 mM AgNO3. The resulting AgNPs exhibited stable physicochemical properties, including a negative zeta potential (-31.5 ± 1.53 mV), ensuring colloidal stability and long-term storage suitable for biomedical drug delivery applications. Dynamic Light Scattering (DLS) analysis confirmed successful conjugation of the synthesized AgNPs with EPI with the hydrodynamic diameter increasing from 202.4 ± 34.38 nm (for unconjugated AgNPs) to 329.1 ± 6.732 nm for AgNP-EPI. The encapsulation efficiency (43.32% ± 0.0593) demonstrated the ability of the synthesized AgNPs to carry sufficient drug payloads, a critical factor in achieving effective therapeutic concentrations while minimizing the frequency of administration. Drug release kinetic studies revealed a controlled dual release mechanism involving diffusion and erosion, as supported by |
| Degree Course | Master of Science in Chemical Engineering |
| Language | English |
| Keyword | rice straw; silver nanoparticles; bio-based method; cancer therapy; drug release |
| Material Type | Thesis/Dissertation |
Preliminary Pages
773.05 Kb
Category : F - Regular work, i.e., it has no patentable invention or creation, the author does not wish for personal publication, there is no confidential information.
Access Permission : Open Access